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Makran subduction located at the northwest of the Indian Ocean nearby the southern coast of Iran and Pakistan. Makran subduction is the source of tsunamis that threaten southern coast of Iran. In this article, generation and propagation of 1945’s tsunami initiated by Makran subduction is simulated. For the three dimensional generation of the wave, advanced algorithm of Okada is adopted. The CFD based software of Flow 3D is applied for global and regional numerical simulation of tsunami wave propagation. In the first stage the 3D propagation of the wave in Oman sea and Indan Ocean is simulated. The presented approach in this paper including the accurate 3D generation of the tsunami wave using the Okada algorithm and two stages propagation in the global and regional models results in a more accurate results in terms of time duration and tsunami wave run-up.